Our   team   investigates   the   human   genetic   disorder, ataxia-telangiectasia     (A-T).     A-T     is     a     multisystem genome   instability   syndrome.   It   involves   cerebellar degeneration   that   leads   to   progressive   neuromotor dysfunction,                  immunodeficiency,      chromosomal instability,       cancer       predisposition,       and       acute sensitivity     to     agents     that     induce     double-strand breaks   (DSBs)   in   the   DNA.   A–T   is   caused   by   mutations in      the      ATM      (ATM      serine/threonine      kinase      or ataxia–telangiectasia     mutated)     gene,     which     was cloned      in      1995.      ATM      is      located      on      human chromosome   11   (11q22.3)   and   is   made   up   of   69   exons spread across 150kb of genomic DNA. We     are     principally     focused     on     the     biomolecular mechanism   of   action   of   dexamethasone   since   several evidences   demonstrated   its   benefit   in   patients   with A-T,   but   also   the   overall   ATM   signaling   and   new   ATM functions are studied. The team: Mauro Magnani Full  Professor of Biochemistry link Michele Menotta Ph.D. Associate Professor of Biochemistry link Anastasia Ricci Postdoctoral Researcher Federica Biancucci Ph.D. student Michela Flamini Fellowship Gianluca Morganti Fellowship Past collaborators: Sara Orazi Ph.D. Chiara Spapperi Fellowship